The interface blows, for starters. Good luck switching from melee to ranged in a pinch if what you're looking for wasn't your last weapon used. Interactivity, such as light switches, is uneven, some switches are textures, some are models and operable and some are models but inoperable, as an example. The graphics actually aren't any good, with the exception of the character models which are excellent. My main beef with the graphical presentation is with the textures which look plain awful. Check out the "Die My Darling" poster during tutorial, which, as I stated in a thread earlier "looks like something out of Duke Nukem 3D", this kind of shoddy texture work is just bizarre and I would think unacceptable by now, especially on the goddamn Source engine.
Then of course we move on to actual gameplay. Melee combat is just a matter of hitting the left mouse button a lot while strafing or pressing forward or back till the d00ds fall over. Then glowing blue smoke highlights their dropped goods to help you spot them in case you're partially blind, or wearing sunglasses. The game world, as you've probably read, is seperated into hubs, just like Deus Ex 2, which coincidentally, Bloodlines feels a lot like. The creepiest similarity being the dance clubs which are almost carbon copies of one another, except DX2's was bigger.
Which brings us to my next point, every building is just a quest station, you enter and immediately can pinpoint who the important NPCs are, there is little exploration, as all unecessary areas are locked by magic padlocks that won't open regardless of your lockpick skill. For instance, it seems that all public restrooms have been shielded against Vampiric entrance by garlic doorknobs, also present on all but two apartments in your building. This kind of streamlining is par for the course in Bloodlines.
I can't comment on the quality or lack therof of the actual dialogue as I'm playing as a Nosferatu, I'm sure Exitium will tell you it's revolutionary or some shit though. The whole game world just feels barren and stiflingly restricted, even with all those NPCs walking around who don't do shit. Which I guess is fine for a lot people who don't like having to go far to get their quests, but you're not even offered the illusion of freedom. I guess my main problem with Bloodlines is it just doesn't feel right, there are so many little problems and oddities, like, why do the cops walk around with their guns out at all times? Why does cloth (coats, skirts, etc) flap around like it's being pulled by fishing wire in ten different directions at all times?
Admitedly I haven't gotten far in the game, so some of these points I've made are subject to change. I should note that I felt similarly about KotOR, a walled in quest farm with mediocre combat, so if you liked that, you should like this.