That still doesn't really mean anything because there's no substantial changes to the game lore that can't be immediately retconned.
You mean like the ghouls that now require some magical medicine, that makes no sense that it exists, and would have to be spread all over the country because not every ghoul in the wasteland is feral?
How about the Master never finding Vaults 31 to 33 or Vault 4 in his backyard? He was in Los Angeles for 10 years and those vaults were all above ground.
What's the retcon that explains why Shady Sands is in Los Angeles when it's always been on the outskirts of Fresno?
How about the OSI in Camp McCarran still getting equipment shipments from Shady Sands in 2281 when it supposedly fell in 2277?
Oh, how about Alice McLafferty talking about the power grid from Hoover Dam to Shady Sands in 2281? Before you say communications, HAM Radios exist in Fallout, and Bethesda added them. You can also walk from Fresno(Shady Sands) to the Hoover Dam in 6 days - the long way.
How about Kimball getting re-elected when the capitol of the NCR supposedly fell during his first term? It's said in several places that his biggest negative is that he has failed to bring the Mojave in to the NCR.
Caesar doesn't know anything about Shady Sands falling when you talk to him in 2281 and he's got a laundry list of things he thinks are weak about the NCR. Again, 6 day walk from where he is and Shady Sands.
Kind of interesting that Vault-Tec supposedly nuked the United States when it's said in several games that China did it. I guess they just don't want to offend China these days. We'll also just ignore how retarded it is that the big plan to make money is to kill off the majority of your consumers, wreck everything remotely considered infrastructure and evaporate the economy. The Underpants Gnomes in South Park had a better grasp of obtaining profit than these people.